I am responsible for teaching Physical Chemistry to Univ undergraduates. In the Department of Chemistry I lecture in final year option course in Biophysical Chemistry.
I run a research group interested in the biophysics of proteins. We explore the fascinating behaviour of these fundamental building blocks of life with a range of approaches, characterising their structure and quantifying their motions. This allows us to address the fundamental questions of how they assemble; interact with other components of the cell; and malfunction in disease.
Articles & publications
Dissecting heterogeneous molecular chaperone complexes using a mass spectrum deconvolution approach Stengel, F., Baldwin, A.J., Bush, M.F., Hilton, G.R., Lioe, H., Basha, E., Jaya, N., Vierling, E. & Benesch, J.L.P. Chem & Biol. (2012), 19, 599-607
The polydispersity of αB-crystallin is rationalised by an interconverting polyhedral architecture Baldwin A.J., Lioe, H., Hilton, G.R., Baker, L.A., Rubinstein, J.L., Kay, L.E. & Benesch, J.L.P. Structure (2011), 19, 1855-63
Mass spectrometry: come of age for structural and dynamical biology Benesch, J.L.P. & Ruotolo, B.T. Curr. Op. Struc. Biol. (2011), 21, 641-9
αB-crystallin polydispersity is a consequence of unbiased quaternary dynamics Baldwin A.J., Lioe, H., Robinson, C.V., Kay, L.E. & Benesch, J.L.P. J. Mol. Biol. (2011), 413, 297-309
Quaternary dynamics and plasticity underlie small heat shock protein chaperone function Stengel, F., Baldwin, A.J., Painter, A.J., Jaya, N., Basha, E., Kay, L.E., Vierling, E., Robinson, C.V. & Benesch, J.L.P. Proc. Natl. Acad. Sci. U.S.A. (2010), 107, 2007-12