Supernumerary Fellow in Medicine; Professor of Immunology
I supervise DPhil, MSc and FHS undergraduate students.
The main objective of my group’s research is to focus on the functional aspects of the antigen specific T cells and studying the factors affecting T cells in controlling virus infection and cancer development.
For important human infections, cancer development and the course of disease is influenced mainly by the T cell response – while a robust and appropriate T cell response is beneficial to the host, a weak or inappropriate response can be ineffective or even have a detrimental effect. Numerous factors influence the quality of the T cell response to viral infections, predominant among them being the microenvironment of the infection site, the type of cells infected and the variability of the virus. By understanding the key factors required for efficient viral control by the T cell response in a number of different viral infections and viral associated cancer, we aim to augment and control the immune response to as a way of improving the outcome of in several important human diseases. Current research program including:
- To define the impact of IFTIM3 genetic variation on Influenza, and other virus infection, immune responses and disease outcome
- To study the Viral OncoProtein(VOP) and Tumor Specific Protein(TSP) specific T cell responses in virus associated cancer (I.e. HBV/HCC; EBV/NPC and HPV/CC)
- To identify the factors determining functional avidity and anti-viral/cancer efficacy of antigen specific T cells in cancer micro-environment
Culshaw et al, Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response. Nat Immunol. 2017 Sep 25. doi: 10.1038/ni.385
NAKAYA HI et al, Proc Natl Acad Sci U S A, 113 (7), pp. 1853-1858.
DONG T. 2015. CD8+ cytotoxic T lymphocytes in human influenza virus infection. Natl Sci Rev, 2 (3), pp. 264-265.
BRIDGEMAN A, et al, 2015. Viruses transfer the antiviral second messenger cGAMP between cells. Science, 349 (6253), pp. 1228-1232.
PENG Y, et al, . 2015. Boosted Influenza-Specific T Cell Responses after H5N1 Pandemic Live Attenuated Influenza Virus Vaccination. Front Immunol, 6 (JUN), pp. 287.
ZHANG YH et al, 2013. Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun, 4 pp. 1418.
ZHAO Y et al, . 2012. High levels of virus-specific CD4+ T cells predict severe pandemic influenza A virus infection. Am J Respir Crit Care Med, 186 (12), pp. 1292-1297.
RAJAPAKSA US et al, Proc Natl Acad Sci U S A, 109 (33), pp. 13353-13358.
WILKINSON TM et al, 2012. Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med, 18 (2), pp. 274-280.
LEE LY, et al, 2008. Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. J Clin Invest, 118 (10), pp. 3478-3490.
ROWLAND-JONES S, DONG T. 2006. HIV – Tired T cells turn around NATURE, 443 (7109), pp. 282-283.