Roger Gundle

Roger Gundle

Supernumerary Fellow in Medicine; Honorary Senior Clinical Lecturer in Orthopaedic Surgery

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I give tutorials to first and second year undergraduate medical students in human anatomy and embryology, which are the greater part of the ‘Organisation of the Body’ paper.  I have done this at Univ since 1989 and for fewer years for two other Oxford Colleges.

As part of my clinical work as Consultant Orthopaedic Surgeon and Hon Senior Clinical Lecturer in Orthopaedic Surgery I teach surgery to clinical medical students.  I teach junior hospital doctors and higher surgical trainees and Fellows in Orthopaedic Surgery.

I help with national and international instructional courses in orthopaedic surgery, and, In recent years, have taught on courses in arthroplasty surgery in Ethiopia and Zimbabwe.


On the clinical front I participate in clinical trials looking at outcomes of surgical interventions in the field of hip and knee surgery.  I am part of the group which first identified adverse reactions to metal-on-metal hip replacement implants which led to a worldwide change in clinical practice.  We have recently completed a multicentre trial comparing oral and intravenous antibiotic therapy following surgery for musculoskeletal infection.  This will have a major impact on resource utilisation in this field.

On the basic science front I collaborate with Professor Paul Bowness and his research group on studies of the cellular and humoral mechanisms of disease activity in the spondyloarthritides and other inflammatory joint diseases.

Selected Publications

Dawson J, Fitzpatrick R, Gundle R, Murray D (1999). Provision of primary total hip replacement surgery. Lancet: 353; 2161

Dalbeth N, Gundle R, Davies RJ, Lee YCG, McMichael AJ and Callan MFC (2004). CD56 bright natural killer cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal programme of activation. Journal of Immunology: 173; 6418-6426

Chan A, Filer A, Parsonage G, Kollnberger S, Gundle R, Buckley C D and Bowness P (2008). Mediation of the proinflammatory cytokine response in rheumatoid arthritis and spondylarthritis by interactions between fibroblast-like synoviocytes and natural killer cells. Arthritis and Rheumatism: 58; 707-717

Pandit H, Glyn-Jones S, McLardy-Smith P, Gundle R, Whitwell D, Gibbons CL, Ostlere S, Athanasou N, Gill HS and Murray DW (2008). Pseudotumours associated with metal-on-metal hip resurfacings. Journal of Bone and Joint Surgery: 90-B; 847-851

Grammatopoulos G, Pandit H, Kwon Y-M, Gundle R,  McLardy-Smith P, Beard DJ, Murray DW and Gill HS (2009). Hip resurfacings revised for inflammatory pseudotumour have a poor outcome. Journal of Bone and Joint Surgery: 91-B; 1019-1024

P Bejon, A Berendt, B. L. Atkins, N. Green, H. Parry, S. Masters, P. Mclardy-Smith, R. Gundle, I. Byren (2010). Two-stage Revision for Prosthetic Joint Infection: Predictors of Outcome and the Role of Re-implantation Microbiology. Journal of Antimicrobial Chemotherapy: 65; 569-575

Murray DW , Grammatopoulos G, Pandit H, Gundle R, Gill HS and McLardy-Smith P (2012). The ten-year survival of the Birmingham hip resurfacing: an independent series. Journal of Bone and Joint Surgery: 94-B; 1180-1186

Glyn-Jones S, Thomas GE, Garfjeld-Roberts P, Gundle R, Taylor A, McLardy-Smith P and Murray DW (2015).  The John Charnley Award: Highly Crosslinked Polyethylene in Total Hip Arthroplasty Decreases Long-term Wear: A Double-blind Randomized Trial. Clinical Orthopaedics and Related Research: 473; 432-438

De Wit J, Al-Mossawi H, Huhn M, Arancibia-Carcamo C, Doig K, Kendrick B, Gundle R, Taylor P, McClanahan T, Murphy E, Zhang H, Barr K, Miller J, Hu X, Aicher T, Morgan R, Glick G, Zaller D, Correll C, Powrie F, Bowness P (2016).  Retinoid-related orphan receptor-γt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease. Journal of Allergy and Clinical Immunology: 137; 960-963

Grammatopoulos G, Kendrick B, Athanasou N, Atkins B, McNally M, McLardy-Smith P, Taylor A and Gundle R (2017). Outcome following Debridement, Antibiotics and Implant Retention (DAIR) In Hip Peri-Prosthetic Joint Infection – An 18-year experience. Journal of Arthroplasty: 32; 2248-2255

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