Roland Armstrong

Roland Armstrong

Junior Research Fellow in Chemistry

Teaching

I currently teach the 1st year Organic Chemistry course for the Department of Biochemistry at Magdalen College and have previously taught this course to Brasenose College undergraduates. I also supervise 4th year undergraduate students in the laboratory.

Research

Chiral compounds can exist in either a left- or right-handed form. This property is of great importance because the molecules of life (for example enzymes, carbohydrates and DNA) are capable of recognising the difference between the two mirror forms of a chiral molecule. My research is principally focussed on the development of new catalytic enantioselective methods for organic synthesis. I have expertise in the areas of organocatalysis, atropisomerism, organoboron chemistry and transition-metal catalysis. I am currently working in the Department of Chemistry, where my research is directed towards developing new transition-metal catalysed processes for enantioselective C-C bond formation.

Selected Publications

Control of Absolute Stereochemistry in Transition-Metal-Catalyzed Hydrogen Borrowing Reactions, Timothy Kwok, Oskar Hoff, Roly J. Armstrong and Timothy J. Donohoe, Chem. Eur. J., 2020, ASAP, DOI: 10.1002/chem.202001253.

Enantioconvergent Alkylation of Ketones with Racemic Secondary Alcohols via Hydrogen Borrowing Catalysis, Daniella M. J. Cheang, Roly J. Armstrong, Wasim M. Akhtar, and Timothy J. Donohoe, Chem. Commun., 2020, 56, 3543.

Chemo- and Regioselective Synthesis of Acyl-Cyclohexenes by a Tandem Acceptorless Dehydrogenation-[1,5]-Hydride Shift Cascade, Lewis B. Smith, Roly J. Armstrong, Daniel Matheau-Raven and Timothy J. Donohoe, J. Am. Chem. Soc., 2020, 142, 2514.

A Hydrogen Borrowing Annulation Strategy for the Stereocontrolled Synthesis of Saturated Aza-Heterocycles, Anna E. R. Chamberlain, Kieran J. Paterson, Roly J. Armstrong, Heather C. Twin, and Timothy J. Donohoe, Chem. Commun., 2020, 56, 3563.

Catalytic Asymmetric Synthesis of Cyclohexanes by Hydrogen Borrowing Annulations, Roly J. Armstrong, Wasim M. Akhtar, Tom A. Young, Fernanda Duarte and Timothy J. Donohoe, Angew. Chem. Int. Ed. 2019, 58, 12558.

Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5 + 1) Annulation Strategy, Wasim M. Akhtar, Roly J. Armstrong, James R. Frost, Neil G. Stevenson, Timothy J. Donohoe, J. Am. Chem. Soc. 2018, 140, 11916.

Enantiodivergent Synthesis of Allenes by Point to Axial Chirality Transfer, Roly J. Armstrong, Meganathan Nandakumar, Rafael M. P. Dias, Adam Noble, Eddie L. Myers and Varinder K. Aggarwal, Angew. Chem. Int. Ed. 2018, 57, 8203.

Stereodivergent Olefination of Enantioenriched Boronic Esters, Roly J. Armstrong, Cristina García-Ruiz, Eddie L. Myers, and Varinder K. Aggarwal, Angew. Chem. Int. Ed. 2017, 56, 786.

Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling, Roly J. Armstrong, Worawat Niwetmarin and Varinder K. Aggarwal, Org. Lett. 2017, 19, 2762.

Catalytic Enantioselective Synthesis of Atropisomeric Biaryls by a Cation-Directed O-Alkylation, John D. Jolliffe, Roly J. Armstrong and Martin D. Smith, Nat. Chem. 2017, 9, 558.

Catalytic Enantioselective Synthesis of Atropisomeric Biaryls: A Cation Directed Nucleophilic Aromatic Substitution Reaction, Roly J. Armstrong and Martin D. Smith, Angew. Chem. Int. Ed. 2014, 53, 12822.

For a full publication list, see orcid.org

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